DNA Methylation
MethylPath™
MeDNA IP-on-Chip | Query qPCR

Genome-wide discovery, identification, validation, and quantitation of methylated sites or genomic regions

Assays include: MeDNA IP experimental design and consultation, 5-Me-C antibody, performance of MeDNA IP assay, post-MeDNA IP QC by PCR, amplification or library generation, post-amplification QC by PCR, and comprehensive data analysis

Price: Inquire

DNA methylation—a chemical modification of DNA that acts as an off-off switch for genes—occurs through the reversible addition of methyl groups at cytosines within CpG dinucleotides. DNA methylation can prevent binding of transcription factors to their binding motifs and can also recruit proteins that promote transcriptional repression. Methylation DNA IP studies have the potential to dramatically advance understanding of the epigenetic basis of disease development and progression, identify valuable new biomarkers for earlier-stage disease diagnosis, and enable development of effective new therapeutics that target modification of the epigenome. In addition to providing mechanistic information on gene regulation, measurements of global methylation patterns can be informative in distinguishing populations of interest and may also provide useful biomarkers.

MethylPath™ enables accurate, reproducible identification of methylated DNA regions across the genome with high sensitivity and specificity, enabling identification of tissue- or disease-specific DNA methylation patterns, identification of novel methylation profile biomarkers for disease onset and progression, and correlation of methylation status directly with expression profiles.

Genpathway Sample Preparation for DNA Methylation Assays >