Overview

Chromatin immunoprecipitation (ChIP) is a powerful tool for evaluating the association of protein-specific regions of the genome. The ChIP assay determines whether a certain protein-DNA interaction is present at a given location, condition, and time point. Genpathway's novel assays, software, tools, and services are based on proprietary Whole-Genome Chromatin and Methylated DNA ChIP Sequencing Technology developed by Genpathway to advance understanding of gene regulation and genetic pathways through genome-wide study of transcription factor binding, gene transcription, and epigenetic events such as DNA methylation and histone modifications. Our ChIP technology generates precise and comprehensive information that reveals causal pathways of disease or predictive pharmacological action of experimental drugs and is widely applicable in targeted drug discovery, drug research and development, and gene and protein diagnostic biomarker discovery and development.

Genpathway ChIP-Seq Technology
Chromatin immunoprecipitation (ChIP) identifies and monitors regions of the genome associated with specific proteins that are crucial for vital cellular functions. The technique involves crosslinking of proteins with DNA, fragmentation and preparation of soluble chromatin, followed by immunoprecipitation with an antibody recognizing the protein of interest. Genpathway then identifies the segment of the genome associated with the protein using highly optimized protocols and procedures for sequencing (ChIP-Seq), microarray tiling (ChIP-on-chip), or qPCR amplification of the DNA in the immunoprecipitate.